Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive, tight-binding dibenzofuran inhibitor TF107 (5)

Protein Data Bank Japan2024-01-17 更新2026-03-21 收录

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Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive, tight-binding dibenzofuran inhibitor TF107 (5) Descriptor: 1,3-bis(chloranyl)-6-[(~{E})-(4-methoxyphenyl)iminomethyl]dibenzofuran-2,7-diol, ACETATE ION, Casein kinase II subunit alpha, ... Authors: Schnitzler, A, Gratz, A, Bollacke, A, Weyrich, M, Kucklaender, U, Wuensch, B, Goetz, C, Niefind, K, Jose, J. Deposit date: 2017-02-25 Release date: 2018-02-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.643 Å) Cite: A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors. Pharmaceuticals, 11, 2018

人类蛋白激酶CK2（Protein kinase CK2）催化亚基与ATP竞争性紧密结合型二苯并呋喃类抑制剂TF107 (5)共晶的晶体结构描述符：1,3-二氯-6-[(E)-(4-甲氧基苯基)亚氨基甲基]二苯并呋喃-2,7-二醇、乙酸根离子、酪蛋白激酶II α亚基（Casein kinase II subunit alpha）等作者：Schnitzler, A、Gratz, A、Bollacke, A、Weyrich, M、Kucklaender, U、Wuensch, B、Goetz, C、Niefind, K、Jose, J 沉积日期：2017-02-25 发布日期：2018-02-28 最后修改日期：2024-01-17 实验方法：X射线衍射（1.643埃）引用：《二苯并呋喃酮与人类蛋白激酶CK2守门残基Phe113的π-卤键构建强效紧密结合抑制剂》，《Pharmaceuticals》，第11卷，2018年

创建时间：

2017-02-25