Supplementary Material. The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer’s disease brain.
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Supplementary
Material. The
histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer’s
disease brain.
Background
Several
epigenome-wide association studies of DNA methylation have highlighted
altered DNA methylation in the ANK1 gene
in Alzheimer’s disease brain samples. However, no study has specifically examined
ANK1 histone modifications in the
disease.
Methods
We
use chromatin immunoprecipitation-qPCR to quantify tri-methylation at histone
3 lysine 4 (H3K4me3) and 27 (H3K27me3) in the ANK1 gene in entorhinal cortex from donors with high (N= 59) or
low (N=29) Alzheimer’s pathology.
Discussion
We
demonstrate decreased levels of H3K4me3, a marker of active gene
transcription, with no change in H3K27me3, a marker of inactive genes.
H3K4me3 is negatively correlated with DNA methylation in specific regions of
the ANK1 gene.
Conclusions
Our
study suggests that the ANK1 gene
shows altered epigenetic marks indicative of reduced gene activation in
Alzheimer’s disease.
创建时间：
2021-03-29
