Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 3g

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 3g Descriptor: (2~{S},3~{S},4~{S},5~{S})-2-heptyl-5-(hydroxymethyl)pyrrolidine-3,4-diol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. Deposit date: 2024-09-18 Release date: 2025-10-01 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025