Glucokinase-Activating Sesquinlignans from the Rhizomes of Acorus tatarinowii Schott
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Three novel sesquinlignans, tatanans A (1), B (2), and C (3), have been isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were established by spectroscopic techniques and single-crystal X-ray analysis. Tatanans A−C potently increase GK enzymatic activity with EC1.5 values in the range of 0.16−1.85 μM. The potent GK activity and unique structural features of tatanans make them promising leads for therapeutic development of antihyperglycemic drugs.
创建时间：
2016-02-23
