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Sequencing and analysis of hematopoietic progenitors and lineage cells, small RNA
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创建时间：
2023-10-13
相关数据集
Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
NIAID Data Ecosystem100
Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [ChIPmentation]
Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate their differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2
NIAID Data Ecosystem20
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [ATAC-seq]. MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia [ATAC-seq]
The transcription factor MECOM, located at 3q26, is essential for hematopoietic stem cells (HSCs) in healthy individuals. Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECO
NIAID Data Ecosystem00
Genome-wide epigenome mapping in human induced pluripotent cells in WT and KMT2CKO cells. [ATAC-Seq]
KMT2C is a histone methyltransferase that mono-methylates lysine four at enhancer regions. This study compares the open and closed chromatin region between WT and KMT2C KO cells and further evaluates
NIAID Data Ecosystem60
Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator
In the fission yeast Schizosaccharomyces pombe the nrd1(+) gene encoding an RNA binding protein negatively regulates the onset of differentiation. Its biological role is to block differentiation by re
PubMed Central10
