The marine worm Capitella teleta is sensitive to neurochemical manipulation, as revealed via a novel high-throughput behavioural tool

The presence of compounds such as pharmaceuticals and pesticides act as neurochemicals in aquatic organisms.This repository contains the raw data from a study investigating the effects of neuromodulatory chemicals in the marine polychaete worm Capitella teleta. We investigated the effects of nicotine, fluoxetine, apomorphine and phenobarbital, which are known to interact with acetylcholine, serotonin, dopamine and GABA pathways. We measured locomotory behaviour using a high throughput multi-well plate assay, using parameters such as total distance moved, time spent moving, time spent at the edge and maximum velocity. We also performed RNA extraction and sequencing with juvenile and adult worms to determine if genes in the pathway were expressed. We share gene sequences, alignments, motif searching, and phylogenetic analysis files for each receptor (with acetylcholine, serotonin, dopamine and GABA) and videos, together with raw .fasta files for RNA sequencing and R code for processing/analysis