Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D‑aspartate receptors during brain development leading to neurodegeneration with impairment in learning and memory in aging
收藏Organisation for Economic Co-operation and Development2026-04-11 收录
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This AOP links chronic NMDA receptors inhibition during brain development to neurodegeneration in hippocampus and cortex with amyloid plaque deposition and tau hyperphosphorylation, and impairment of learning and memory, which are considered as hallmark of Alzheimer's disease. It makes use of some KEs and KERs from AOP 13 and introduces...
