Copper-Catalyzed Aerobic Oxidative [2 + 3] Cyclization/Aromatization Cascade Reaction: Atom-Economical Access to Tetrasubstituted 4,5-Biscarbonyl Imidazoles

An
atom-economical method for accessing tetrasubstituted 4,5-biscarbonylimidazoles
by reaction between glycine derivatives and 5-alkoxyoxazoles is reported.
The method, which involves a copper-catalyzed aerobic oxidative [2
+ 3] cyclization/aromatization cascade process, starts from readily
available and inexpensive materials, uses molecular oxygen as a co-oxidant,
and has a broad substrate scope.

本报告提出了一种基于甘氨酸衍生物与5-烷氧基恶唑反应制备四取代4,5-双羰基咪唑的方法。该方法涉及铜催化的气动氧化[2+3]环化/芳香化级联反应过程，以易于获取且价格低廉的原材料为起始，利用分子氧作为共氧化剂，并具有广泛的底物适用范围。