Published transdifferentiation protocols used to evaluate our genomic model of cell identity.

We obtained genomic data (E = gene expression RNA-seq, P = Polycomb-associated H3K27me3 ChIP-seq, H = Heterochromatin-associated H3K9me3 ChIP-seq) for pairs of mouse and human tissues with published transdifferentiation protocols. Genomic datasets are listed in Table S1. Asterisks (*) mark genes that were not included in our testing, because they were not transcription factors (Baf60c) or were knocked-down in the protocol (p19(Arf)). Cross (+): two sources of data were used for human neural stem cells: cortex-derived neurospheres and in vitro derived neural progenitor cells. We assume that the published transdifferentiation protocols apply to both human and mouse cells.