Data File S13. Genetic interaction enrichment among protein complexes

This file lists all possible pairs of protein complexes tested in the ExE, NxN and ExN networks. Enrichment for negative and positive interactions between genes in the same complex or between genes in different complexes is indicated. In addition, enrichment for genetic interaction in general (Combined interaction enrichment) regardless of the type is also indicated. Finally, Interaction Sign Bias indicates the distribution of interactions between genes within the same complex or between genes in different complexes. The interaction sign bias is computed as the mean over all interactions for within a given complex or between a pair of complexes. For example, an interaction sign bias of -1 indicates that all interactions identified between a set of genes encoding complexes members are negative, whereas a score of 1 indicates that only positive interactions were identified between a particular set of protein complex encoding genes. Rows highlighted in blue indicated complex-complex pairs enriched for negative interactions where greater than 75% of all interactions detected were negative. Rows highlighted in yellow indicated complex-complex pairs enriched for negative interactions where greater than 75% of all interactions detected were positive. The analysis shown in Fig. 7 is based on subset of complexes composed of 75% essential genes (i.e. considered essential complexes) or 75% nonessential genes (i.e. considered nonessential complexes). The complexes used for this analysis and their enrichment results are listed in the tabs labeled, “_filtered”. The tabs named “all” list within and between complex enrichment for all protein complexes without prior filtering of complexes composed of less than 75% essential or 75% nonessential genes.