The role of adiponectin in ischemia-reperfusion syndrome: a literature review

ABSTRACT Adiponectin, among other diverse adipokines, is produced in greater quantity and has an effect on the adipose tissue and other tissues in the body. Adiponectin plays three main roles: regulatory metabolic and sensitizing function of insulin in the liver and muscles; it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. Since many situations resulting from traumatic accidents or pathologies are due to cell damage caused by ischemia-reperfusion syndrome, it is relevant to study new therapeutic alternatives that will contribute to reducing these lesions. The objective of this study is to carry out a literature review on the role of adiponectin in ischemia-reperfusion syndrome.

摘要 脂联素（Adiponectin）作为多种脂肪因子（adipokines）中的一类，其生成量更为丰富，可作用于脂肪组织及全身其他组织。脂联素主要具备三大核心功能：其一可调节代谢并增强肝脏与肌肉的胰岛素敏感性；其二可作为抗炎细胞因子发挥作用，并参与血管保护；此外在缺血再灌注综合征（Ischemia-Reperfusion Syndrome）发生时，还能发挥关键的心脏保护作用。鉴于诸多创伤事故或病理状态引发的临床病症均由缺血再灌注综合征导致的细胞损伤所引发，因此探索可减轻此类损伤的新型治疗方案具有重要研究价值。本研究旨在针对脂联素在缺血再灌注综合征中的作用开展文献综述。