MMP7

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

本基因编码了基质金属蛋白酶（MMPs）家族中的肽酶M10成员。该家族的蛋白质参与正常生理过程中的细胞外基质的降解，例如胚胎发育、生殖和组织重塑，以及疾病过程，如关节炎和转移。编码的前体蛋白经过蛋白水解处理生成成熟的蛋白酶。该分泌型蛋白酶能够降解蛋白聚糖、纤连蛋白、弹性蛋白和酪蛋白，与大多数MMP家族成员不同的是，它缺乏保守的C端血蓝蛋白结构域。该酶参与伤口愈合，小鼠研究显示它调节肠道粘膜防御素的活动。该基因位于11号染色体上MMP基因簇中。该基因在多种人类癌症中表现出升高的表达水平。[由RefSeq提供，2016年1月]