Isolation and Structure of Providencin: A Highly Oxygenated Diterpene Possessing a Unique Bicyclo[12.2.0]hexadecane Ring System from the Sea Plume <i>Pseudopterogorgia kallos</i>
收藏NIAID Data Ecosystem2026-03-06 收录
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Providencin (1) is a naturally occurring cytotoxin isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed bicyclo[12.2.0]hexadecane ring system and was established through spectroscopic analysis and X-ray crystallographic analysis. Providencin (1) was shown to exhibit modest anticancer activity against human breast (MCF7), lung (NCI-H460), and CNS (SF-268) cancer cell lines.
创建时间：
2016-08-20
