Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=9b1e9ba5f92950a9f4069e26a2f3de86
下载链接
链接失效反馈官方服务：
资源简介：
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss.
提供机构：
Harvard Medical School
创建时间：
2022-02-20
