Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3
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资源简介：
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss.
创建时间：
2022-02-20
