Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide Descriptor: 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ... Authors: Leitans, J, Tars, K. Deposit date: 2023-02-25 Release date: 2023-12-13 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. J.Med.Chem., 66, 2023

人类碳酸酐酶IX（human carbonic anhydrase IX）与磺胺类（sulfonamide）配体的复合物三维结构，配体标识为：5-(5-甲基-6-喹啉-5-基-吡啶-3-基)噻吩-2-磺酰胺。实验涉及碳酸酐酶9、甘油（GLYCEROL）等。作者：莱坦斯（Leitans, J）、塔尔斯（Tars, K）。存档日期：2023-02-25；发布日期：2023-12-13；最后修订日期：2024-11-20。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3埃。引用文献：《阻旋/构型翻转灵活性：碳酸酐酶自适应抑制剂的设计合成与抗增殖活性研究工具》，《药物化学杂志》（J.Med.Chem.），2023年，第66卷。