Identifiation of lncRNA expression profiles and ceRNA analysis in the spinal cord of morphine tolerance rats

The mechanism of morphine tolerance remains unclear, and lncRNA have been promising molecule in many pathophysiological processes. However, the role of lncRNA on morphine tolerance hasn’t been explored yet. So we explore this issue, and our results indicated that the expression profiles of lncRNAs have changed in morphine tolerance rats as compared with normal rats, and among those, some differentially expressed lncRNAs might be new therapeutic targets for morphine tolerance. Microarray expression profiling of mRNAs and lncRNAs were conducted using RNA extracted from the spinal cord of five morphine tolerance rats and five normal rats.