Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand

Crystal structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with ligand Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one, GERANYL DIPHOSPHATE, ... Authors: Hunter, W.N, Ramsden, N.L, Ulaganathan, V. Deposit date: 2008-09-22 Release date: 2009-08-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy J.Med.Chem., 52, 2009

与配体结合的2-C-甲基-D-赤藓糖醇2,4-环二磷酸合酶（2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase）晶体结构。描述对象：2-C-甲基-D-赤藓糖醇2,4-环二磷酸合酶、4-氨基-1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-5-氟嘧啶-2-酮、香叶基二磷酸（Geranyl Diphosphate）等。作者：Hunter, W.N.、Ramsden, N.L.、Ulaganathan, V.。提交日期：2008-09-22，发布日期：2009-08-25，最后修改日期：2023-11-01。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.5埃）。引用文献：《基于结构的2-C-甲基-D-赤藓糖醇-2,4-环二磷酸合酶配体发现方法：抗菌治疗靶点》，《Journal of Medicinal Chemistry》，2009年，第52卷。