Efficient Cleavage of Permethylated Cyclodextrins

The
cleavage of a permethylated α-cyclodextrin, that is,
purity and chemical yield of a maltohexaose derivative thus obtained,
was decisively affected by the reaction time. The matrix-assisted
laser desorption ionization time-of-flight mass spectrometry spectra
with synthetic data enable us to improve the cleavage reaction more
efficiently. The optimized conditions developed in the present study
allow us to cleave the permethylated γ-cyclodextrin to afford
a
maltooctaose derivative as a new synthetic building block in a high
chemical yield.