Candindoles A and B, heterozygous terphenyl-indole alkaloids with antifungal and cytotoxic activities from the marine-derived fungus Aspergillus candidus HNNU0546
收藏科学数据银行2025-12-12 更新2026-04-23 收录
下载链接：
https://www.scidb.cn/detail?dataSetId=e8045e563d804d61905b2267b66e5116
下载链接
链接失效反馈官方服务：
资源简介：
Three previously undescribed indole alkaloids candindoles A-C (1-3), along with five known analogues (4-8), were isolated from the marine-derived fungus Aspergillus candidus HNNU0546. Structurally, 1 and 2 represent the first terphenyl-indole piperazine alkaloid hybrids, featuring unprecedented backbones. Their structures including absolute configurations, were elucidated by extensive spectroscopic methods, DP4+ probability analysis and ECD calculations. A plausible biosynthetic pathway for 1 is proposed. Compound 1 exhibited moderate growth-inhibitory activity against the plant pathogenic fungus of Alternaria sp. with an EC50 value of 19.21 ± 0.26 µM, while compounds 1 and 2 showed significant cytotoxicity towards human rhabdomyosarcoma cells A673 with IC50 values of 7.72 and 8.89 µM, respectively, comparable to the positive control cisplatin.
提供机构：
BGI Research; Hainan Normal University; Institute of Deep-Sea Science and Engineering
创建时间：
2025-12-12
