XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

NIAID Data Ecosystem2026-05-02 收录

偶联受体药理

褪黑素受体结构

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XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

创建时间：

2024-10-23

S1P4 First Extracellular Loop Peptidomimetic

偶联受体药理

肽设计

S1P4 First Extracellular Loop Peptidomimetic Descriptor: S1P4 First Extracellular Loop Peptidomimetic Authors: Pham, T.C.T, Kriwacki, R.W, Parrill, A.L. Deposit date: 2006-01-11 Release date: 2007-01-

Protein Data Bank Japan2024-10-16 更新50

Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction

偶联受体药理

变构调节剂设计

Targeting G protein-coupled receptors (GPCRs) through allosteric sites offers advantages over orthosteric sites in identifying drugs with increased selectivity and potentially reduced side effects. In

Figshare2021-11-24 更新30

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization

偶联受体药理

EP2受体拮抗剂

Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comp

NIAID Data Ecosystem30

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology

偶联受体药理

先导化合物

The orphan G protein-coupled receptor GPR55 has been proposed as a novel receptor of the endocannabinoid system. However, the validity of this categorization is still under debate mainly because of th

NIAID Data Ecosystem40

Gene expression analysis comparing rat neonatal cardiomyocytes and human iPSC-cardiomyocytes

心肌细胞基因表达

偶联受体药理

Bulk RNA sequencing of rat neonatal cardiomyocytes and hiPSC-cardiomyocytes treated with vehicle or GPCR agonists for 60 minutes. Bulk RNA sequencing of rat neonatal cardiomyocytes and hiPSC-cardiomyo

NIAID Data Ecosystem30

XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

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