Enrichment clusters and related downregulated DEGs.

Enriched downregulated gene candidates (FC < -1.2, indicated via gene symbols) are depicted for the related categories/cluster terms derived from GO analysis (see also Fig 3) for (A) the RS cortex of female APP/PS1 AD mice, (B) the hippocampus of female APP/PS1 AD mice, (C) the RS cortex of male APP/PS1 AD mice, and (D) the hippocampus of male APP/PS1 AD mice. Note that GO analysis and enrichment did not reveal significant results for the RS cortex of female APP/PS1 AD animals. The Log(10)P values for the individual enriched categories/cluster terms are also provided. Importantly, the number of enriched clusters and related gene candidates is considerably reduced for downregulated compared to upregulated gene candidates (see also Table 1).