RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) mediates conformational conversion of protein substrates to trigger the modulation of protein phosphorylation status. Pin1 was knockdown in the pancreatic adenocarcinoma cell PANC-1 and osteosarcoma cell U2OS. The expression profiles of them were compared to explore the key features regulated by Pin1. The protein levels of Pin1 were knocked down in PANC-1 and U2OS cells with three biological replicates. RNAs were sequenced on an Illumina Novaseq platform. Transcriptomic profilings were compared to analyze the differentially expressed genes.