Lines of Plasmodium falciparum malaria parasites were selected for resistance to candidate antimalarial compounds in vitro and sequenced to determine mutational changes associated with resistance.
Twenty-three aminooxy compounds have been examined for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum in vitro. Eight of these compounds were found to have 50% inhib
We herein report unsymmetrical coupling of 2-methylquinolines under the blue LED light conditions using iridium-based photocatalyst. This methodology represents the direct synthetic method for the β-n
IC50 values (the concentration of compound that gave 50% inhibition of native PDE activity) are mean ± SEM in μM and were calculated using the Prism software package (GraphPad Software, Inc.). Percent
