Quasi Elastic Neutron Scattering Investigations on Gamma Irradiated Hybrid Cellulose Membrane for Uremic Toxin Removal

The efficiency of hemodialysis membranes in removing small uremic toxins, such as urea and creatinine, remains a critical challenge for the treatment of end-stage renal disease (ESRD). To address this issue, we propose a hybrid membrane system composed of cellulose acetate (CA) integrated with mesoporous silica (MS) and surface-modified with poly(ethylene glycol) methyl ether (PEGMEA). This design aims to enhance membrane performance by utilizing the biocompatibility and semi-permeability of CA, the adsorptive capacity of MS, and the hydrophilic, antifouling properties provided by PEGMEA grafting via gamma irradiation at 5 kGy. Structural and morphological characterizations have identified a promising membrane variant, i.e. CA-PEGMEA (5 kGy) hybridized with MS, for further investigation. To gain insight into the molecular-level diffusion of urea, a predominant uremic toxin, we will employ Quasi-Elastic Neutron Scattering (QENS) at physiological temperature (37°C). This study will assess urea dynamics within the hybrid membrane and its individual components, contributing to a deeper understanding of the transport mechanisms critical to dialysis efficacy.