Structural mechanism of CB1R binding to peripheral and biased inverse agonists

Structural mechanism of CB1R binding to peripheral and biased inverse agonists Descriptor: CNb36, Cannabinoid receptor 1,Glycogen synthase, N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide Authors: Kumari, P, Dvoracsko, S, Enos, M.D, Ramesh, K, Lim, D, Hassan, S.A, Kunos, G, Iyer, M.R, Rosenbaum, D.M. Deposit date: 2024-04-03 Release date: 2024-11-20 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural mechanism of CB 1 R binding to peripheral and biased inverse agonists. Nat Commun, 15, 2024CB1R结合外周及偏向性反向激动剂的结构机制 描述符：CNb36、大麻素受体1（Cannabinoid receptor 1）、糖原合酶（Glycogen synthase）、N-[(2S,3S)-4-(4-氯苯基)-3-(3-氰基苯基)丁-2-基]-2-甲基-2-{[5-(三氟甲基)吡啶-2-基]氧基}丙酰胺 作者：Kumari P、Dvoracsko S、Enos M.D、Ramesh K、Lim D、Hassan S.A、Kunos G、Iyer M.R、Rosenbaum D.M. 提交日期：2024-04-03 发布日期：2024-11-20 最后修改日期：2025-05-28 实验方法：电子显微镜（分辨率3.5 Å） 引用文献：CB1R结合外周及偏向性反向激动剂的结构机制. 《自然-通讯》, 15卷, 2024年