Growth Inhibition and Induction of Innate Immune Signaling of Chondrosarcomas with Epigenetic Inhibitors. Growth Inhibition and Induction of Innate Immune Signaling of Chondrosarcomas with Epigenetic Inhibitors

In this study, our results demonstrated preclinical activity of combined DNMT and HDAC inhibition against chondrosarcomas and suggest that targeted epigenetic therapies could effectively augment the immune-reactivity of chondrosarcomas and may sensitize these immune-cold tumors to immune checkpoint blockade. Overall design: 2 RNA-seq samples