Oxidized Low-Density Lipoprotein drives dysfunction of the liver lymphatic system

Single-cell RNA-sequencing revealed that the transcriptional profile of LECs from HFHC livers was consistent with changes in the LEC transcriptome that reflect both proliferation and a potential de-differentiation of liver LECs in the context of disease which may impact their functions, such as permeability and metabolism. Overall design: Liver stromal cells were harvested from mice fed either control or high fat, high cholesterol diet, flow sorted to enrich for endothelial cell populations and subjected to single-cell RNA-seq.