High-quality genome catalog of human oral microbiome expands phylogeny and clinical insights.. human oral metagenome

The human oral microbiome significantly influences health and is linked to various oral diseases. To address gaps in isolate-based genome databases, we developed the Human Reference Oral Microbiome catalog (HROM) with 3,426 species-level genomes. spanning 21 phyla. HROM enables improved classification and highlights distinct traits of gut-oral sharing species.