Correlation between IGFBP-3 serum level and patients' recorded variables.

Abbreviations: IGFBP, insulin-like growth factor binding protein; SSM, superficial spreading melanoma; NM, nodular melanoma; ALM, acral lentiginous melanoma.*A receiver operating characteristic (ROC) curve analysis was used to find an average value of metastatic volume in order to dichotomize the patients into two subgroups. Each measurable metastases, measured according to RECIST guideline, was considered as a spherical formation and the volumes calculated using the following formula: volume = 4/3 π r3.