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成人脊髓组织移植联合他克莫司缓释胶原水凝胶促进脊髓损伤的完全修复
成体脊髓组织移植是治疗脊髓损伤的有效方式，为克服异体移植排斥反应传统全身应用免疫抑制剂的毒副作用较大且难以避免。为解决这一科学问题，本研究构建了一种临床级别的胶原/他克莫司凝胶缓释体系，通过促进异体移植脊髓组织存活、降低应用免疫抑制剂的副作用，提高移植后动物模型的存活，促进全横断脊髓损伤大鼠运动功能恢复。在研究过程中，分别设计了细胞层面实验和动物损伤实验，在分组中设计了单纯脊髓移植对照组，单纯Co
干细胞与再生医学数据中心2023-06-30 更新200
miR-540-3p partially recovers the locomotor function of spinal cord injury mice by targeting SIX4/Yap1 and inactivation of astrocytes
Spinal cord injury (SCI) lacks therapeutic reagents. miRNAs are responsible for mesenchymal stem cells (MSCs) therapy in spinal cord injury. To discover the underlying therapeutic miRNA target and its
Mendeley Data2024-06-29 更新50
DataSheet1_Bioengineered Zinc Oxide Nanoparticle-Loaded Hydrogel for Combinative Treatment of Spinal Cord Transection.PDF
Spinal cord injury (SCI) is one of the most destructive diseases. The neuroinflammation microenvironment needs comprehensive mitigation of damages. Thus, regulation of local, microenvironment drugs co
NIAID Data Ecosystem20
Side effects of steroid use in patients with traumatic spinal cord injury
OBJECTIVE: Indicate and identify potential complications in our unit associated with the use of steroids in patients over 16 years of age with traumatic acute spinal cord injury managed with NASCIS II
DataCite Commons2022-06-07 更新80
Peptide-Tethered Hydrogel Scaffold Promotes Recovery from Spinal Cord Transection via Synergism with Mesenchymal Stem Cells
Spinal cord injury (SCI) is one of the most devastating injuries. Treatment strategies for SCI are required to overcome comprehensive issues. Implantation of biomaterial scaffolds and stem cells has b
NIAID Data Ecosystem40
