The corepressors GPS2 and SMRT control enhancer and silencer function linked to eRNA transcription during inflammatory activation of macrophages. The corepressors GPS2 and SMRT control enhancer and silencer function linked to eRNA transcription during inflammatory activation of macrophages

Study the inflammation-associated Ccl2 functional enhancer and its related enhancer RNA in mice macrophages Overall design: Transcriptome, DNA structure, cristome changes of GPS2 marked enhancer to the target gene expression. Gro-seq is designed to mark the transcribed enhancer regions; ChIP-seq is designed to mark the TF bindings; RNA-seq is designed to evaluate gene expression and 4C-seq is designed to visualize the DNA structure dynamic changes.