the SCOPE-ITSCC metastases study, a prospective multi-center study

Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous-cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors. Of 514 SOTRs who presented with 623 primary cSCCs, 37 developed metastases with a 2-year patient-based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size >2cm, clinical ulceration, poor differentiation grade, perineural invasion and deep invasion. A high-stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2-year cumulative incidence of 46.2% (31.9% – 68.4%).实体器官移植受者（Solid organ transplant recipients, SOTRs）被认为发生转移性皮肤鳞状细胞癌（cutaneous squamous-cell carcinoma, cSCC）的风险显著升高，但目前仍缺乏关于其精确发病率及相关危险因素的可靠数据。在514例实体器官移植受者中，共计出现623例原发性皮肤鳞状细胞癌，其中37例发生转移，以患者为统计基准的2年累积发病率为6.2%。转移相关危险因素包括病灶位于头颈部区域、存在局部复发、病灶直径＞2cm、临床溃疡形成、分化程度不良、神经周围浸润及深部浸润。合并溃疡的高分期肿瘤转移风险最高，其2年累积发病率达46.2%（31.9%～68.4%）。