Iron-Catalyzed C–H Alkylation of Heterocyclic C–H Bonds

An efficient, iron-catalyzed C–H
alkylation of benzothiazoles
by using alkyl diacyl peroxides and alkyl tert-butyl
peresters which are readily accessible from carboxylic acids to synthesize
2-alkylbenzothiazoles is developed. This reaction is environmentally
benign and compatible with a broad range of functional groups. Various
primary, secondary, and tertiary alkyl groups can be efficiently incorporated
into diverse benzothiazoles. The effectiveness of this method is illustrated
by late-stage functionalization of biologically active heterocycles.