Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine

Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine Descriptor: 5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Trimethoprim-sensitive dihydrofolate reductase Authors: Anderson, A.C, Frey, K.M, Liu, J, Lombardo, M.N. Deposit date: 2009-01-07 Release date: 2009-03-24 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol., 387, 2009

金黄色葡萄球菌（Staphylococcus aureus）F98Y突变型二氢叶酸还原酶（dihydrofolate reductase）与烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及2,4-二氨基-5-[3-(3-甲氧基-4-苯基苯基)丁-1-炔基]-6-甲基嘧啶形成的复合物。描述符：5-[(3S)-3-(2-甲氧基联苯-4-基)丁-1-炔-1-基]-6-甲基嘧啶-2,4-二胺、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）、对甲氧苄啶（trimethoprim）敏感的二氢叶酸还原酶（dihydrofolate reductase）。作者：Anderson, A.C、Frey, K.M、Liu, J、Lombardo, M.N。存档日期：2009年1月7日；发布日期：2009年3月24日；最后更新日期：2024年4月3日。实验方法：X射线衍射（分辨率1.85埃）。引用文献：野生型与耐甲氧西林金黄色葡萄球菌（methicillin-resistant Staphylococcus aureus）突变型二氢叶酸还原酶（dihydrofolate reductase）的晶体结构揭示了可能与甲氧苄啶（trimethoprim）耐药相关的NADPH构象变体，《分子生物学杂志》，387卷，2009年。