Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor
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Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor Descriptor: 3'-{[(4-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[(1S)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, UNKNOWN ATOM OR ION Authors: Canevari, G, Re Depaolini, S, Cucchi, U, Forte, B, Carpinelli, P, Bertrand, J.A. Deposit date: 2013-04-30 Release date: 2013-08-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Structural Insight Into Maternal Embryonic Leucine Zipper Kinase (Melk) Conformation and Inhibition Towards Structure- Based Drug Design. Biochemistry, 52, 2013
非磷酸化母源性胚胎亮氨酸拉链激酶（Maternal Embryonic Leucine zipper Kinase, MELK）与吡咯并吡唑类抑制剂的复合晶体结构，抑制剂标识符：3'-{[(4-溴-1-甲基-1H-吡咯-2-基)羰基]氨基}-N-[(1S)-1-苯基-2-(吡咯烷-1-基)乙基]-1',4'-二氢-5'H-螺[环丙烷-1,6'-吡咯并[3,4-c]吡唑]-5'-甲酰胺；该晶体体系包含非磷酸化母源性胚胎亮氨酸拉链激酶、上述吡咯并吡唑类抑制剂以及未知原子或离子
作者：Canevari, G、Re Depaolini, S、Cucchi, U、Forte, B、Carpinelli, P、Bertrand, J.A.
沉积日期：2013-04-30
发布日期：2013-08-21
最后修改日期：2023-12-20
实验方法：X射线衍射（1.83埃）
引用文献：《母源性胚胎亮氨酸拉链激酶构象及其面向基于结构药物设计的抑制机制的结构洞察》，《生物化学》，52卷，2013年
创建时间：
2013-04-30
