Discovery of novel PRMT5 inhibitors bearing a methylpiperazinyl moiety - Supplementary Data

Supplementary Table S1: List of 68 selected compounds via virtual screening and bioactivity evaluation 2. Supplementary Figures: 2.1 Supplementary Figure S1: Jurkat and K-562 cell growth inhibition rates of compounds S1-S68 2.2 Supplementary Figure S2: Anti-proliferative effect of EPZ015666 on Z138 cells 2.3 Supplementary Figure S3: SDMA and PRMT5 levels in Z-138 cells treated by S43, 43b, 43g and the positive control. 2.4 Supplementary Figure S4-S22: NMR and LC-MS spectra of target compounds