Total Synthesis of the Potent cAMP Signaling Agonist (−)-Alotaketal A
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https://figshare.com/articles/dataset/Total_Synthesis_of_the_Potent_cAMP_Signaling_Agonist_Alotaketal_A/2518870
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资源简介：
We have developed a convergent synthetic route to the
potent cAMP
signaling agonist (−)-alotaketal A that employs two stages
of SmI2-mediated reductive allylation reactions for assembling
the polycycle and fragment coupling. Also notable are a Hg(OAc)2-mediated selective alkene oxidation and the subtlety of the
formation of the unprecedented spiroketal ring system. The probes
AKAR4 and ICUE3 were used to evaluate the cAMP singaling agonistic
activity of (−)-alotaketal A and elucidate its structure–activity
relationship.
创建时间：
2012-05-30
