Expert tumor annotations and radiomic features for the ISPY1/ACRIN 6657 trial data collection

This dataset enhances the ISPY1 data collection, with uniformly curated data, tumor annotations, and quantitative imaging features. This dataset includes a) uniformly processed scans that are harmonized to match the intensity and spatial characteristics, facilitating immediate use in computational studies, b) computationally-generated and manually-revised expert annotations of tumor regions, as well as c) a comprehensive set of quantitative imaging (also known as radiomic) features corresponding to the tumor regions.The segmentations for the ISPY1/ACRIN 6657 dataset currently hosted on TCIA’s website describe a) the tumor volume of interest (VOI) and b) functional tumor volume (FTV).<ol><li>The provided tumor VOI is a 3D rectangular box enclosing the enhancing tumor region, while including peritumoral tissue. The VOI provides a general guideline of where the tumor is located within patient anatomy, but it does not delineate tumor boundaries or shape.</li><li>The FTV segmentations describe only enhancing voxels in the tumor, i.e., defined by peak enhancement or signal enhancement ratio criteria.</li></ol>These currently provided segmentations do not include non-enhancing portions of the tumor volume, which represent a significant portion of the disease burden that needs to be studied to better understand and quantify the disease.The segmentations in these new analysis results are for the entire 3D primary lesion, including both the enhancing and the non-enhancing tumor regions, therefore defining the structural tumor volume (STV). These STV annotations were generated by manually delineating the primary lesion volume, after confirming the location of the primary lesion from the provided VOI and FTV. The STV annotations were reviewed and approved by a board-certified, fellowship-trained breast radiologist, and are statistically significantly different from FTV.We believe these STV annotations will allow analyses of the entire disease burden and analyses of tumor heterogeneity regarding contrast uptake, contributing to further expanding our mechanistic understanding of the disease potentially leading to improved patient management.

本数据集丰富了ISPY1数据集，包含了经过统一整理的数据、肿瘤注释以及定量成像特征。该数据集包括以下内容：a) 经过统一处理且强度和空间特性得到协调的扫描图像，便于直接应用于计算研究；b) 通过计算生成并由专家手动修订的肿瘤区域注释，以及c) 与肿瘤区域相对应的全面定量成像（亦称为放射组学）特征集合。目前托管于TCIA网站上的ISPY1/ACRIN 6657数据集的分割描述包括以下内容：a) 肿瘤感兴趣区域（VOI）的体积，以及b) 功能性肿瘤体积（FTV）。<ol><li>所提供的肿瘤VOI是一个包含增强肿瘤区域及其周围组织的3D矩形盒，它为肿瘤在患者解剖结构中的位置提供了一般性的指导，但并不能明确肿瘤的边界或形状。</li><li>FTV分割仅描述肿瘤中的增强体素，即由峰值增强或信号增强比标准定义的。</li></ol>目前提供的分割不包括肿瘤体积中的非增强部分，这些部分代表了疾病负担的重要部分，需要对其进行研究以更好地理解和量化疾病。这些新分析结果中的分割针对整个3D原发性病变，包括增强和非增强肿瘤区域，因此定义了结构性肿瘤体积（STV）。STV注释是在确认了从提供的VOI和FTV中确定的原发性病变位置后，通过手动描绘原发性病变体积生成的。这些STV注释已由具有执业资格且经过进修培训的乳腺放射学家进行审查和批准，且与FTV具有统计学上的显著差异。我们相信这些STV注释将允许对整个疾病负担进行分析，并对肿瘤异质性关于对比剂摄取的分析，从而有助于进一步拓展我们对疾病的机制理解，可能有助于改善患者的管理。