Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine

Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine Descriptor: 1,4-DIAMINOBUTANE, 5'-{[2-(aminooxy)ethyl](methyl)amino}-5'-deoxy-8-methyladenosine, S-adenosylmethionine decarboxylase alpha chain, ... Authors: Bale, S, McCloskey, D.E, Pegg, A.E, Secrist III, J.A, Guida, W.C, Ealick, S.E. Deposit date: 2008-07-29 Release date: 2009-03-10 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.43 Å) Cite: New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine J.Med.Chem., 52, 2009

带有共价结合的5'-[(2-氨氧乙基)甲氨基]-5'-脱氧-8-甲基腺苷的人源S-腺苷甲硫氨酸脱羧酶（Human AdoMetDC）。描述项：1,4-二氨基丁烷、5'-{[2-(氨氧基)乙基](甲基)氨基}-5'-脱氧-8-甲基腺苷、S-腺苷甲硫氨酸脱羧酶α亚基…… 作者：Bale S、McCloskey D.E、Pegg A.E、Secrist III J.A、Guida W.C、Ealick S.E。存档日期：2008-07-29；发布日期：2009-03-10；最后修改日期：2024-11-06。实验方法：X射线衍射（2.43埃）。引用文献：《人源S-腺苷甲硫氨酸脱羧酶抑制剂设计的新认知：S-腺苷甲硫氨酸结构类似物中腺嘌呤C8取代的研究》，J.Med.Chem.，第52卷，2009年。