MME

The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

该基因编码的蛋白质为一种II型跨膜糖蛋白，是常见的急性淋巴细胞白血病抗原，在人类急性淋巴细胞白血病（ALL）的诊断中作为重要的细胞表面标志物。该编码蛋白存在于前B型白血病细胞上，此类细胞占ALL病例的85%。然而，此蛋白并不局限于白血病细胞，亦可在多种正常组织中发现。该蛋白是一种中性内肽酶，能够在疏水性残基的氨基侧切割肽链，并失活包括胰高血糖素、脑啡肽、P物质、神经肽、催产素和缓激肽在内的多种肽激素。[由RefSeq提供，2017年8月]