Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one

Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one Descriptor: 6-hydroxy-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(16),3,5,7,9,13(17),14-heptaen-12-one, Bromodomain-containing protein 4, FORMIC ACID Authors: Lee, B.I, Park, T.H. Deposit date: 2019-07-04 Release date: 2020-07-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.553 Å) Cite: Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Molecules, 26, 2021

BRD4溴结构域1（BD1）与6-羟基-16-甲氧基-11-甲基-2-氧杂-11-氮杂四环[8.6.1.0³,⁸.0¹³,¹⁷]十七碳-1(16),3,5,7,9,13(17),14-七烯-12-酮复合物的晶体结构。描述项：6-羟基-16-甲氧基-11-甲基-2-氧杂-11-氮杂四环[8.6.1.0³,⁸.0¹³,¹⁷]十七碳-1(16),3,5,7,9,13(17),14-七烯-12-酮、含溴结构域蛋白4（Bromodomain-containing protein 4）、甲酸（FORMIC ACID）。作者：Lee, B.I.、Park, T.H.。沉积日期：2019-07-04；发布日期：2020-07-08；最后修改日期：2023-11-22。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.553埃。引用文献：《Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research》，刊载于《Molecules》2021年第26卷。