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A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism

NIAID Data Ecosystem2026-03-08 收录

睡眠稳态调控

PER3基因多态性

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA239782 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2014-02-21

睡眠稳态调控

果蝇遗传学

Recent studies have identified the Drosophila brain circuits involved in the sleep/wake switch and have pointed to the modulation of neuronal excitability as one of the underlying mechanisms triggerin

NIAID Data Ecosystem60

Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila

睡眠稳态调控

果蝇遗传学

Sleep is homeostatically regulated, such that sleep drive reflects the duration of prior wakefulness. However, despite the discovery of genes important for sleep, a coherent molecular model for sleep

NIAID Data Ecosystem50

Effect of 12 hour sleep restriction on the transcriptome of mice carying a human Per3 polymorphism. Mus musculus

睡眠剥夺基因表达

PER3基因多态性

In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostat

NIAID Data Ecosystem30

Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity

睡眠稳态调控

饮食对睡眠的影响

Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where anim

NIAID Data Ecosystem60

Effect of ultradian light-dark cycles on the transcriptome of mice carying a human Per3 polymorphism

睡眠稳态调控

基因多态性

NIAID Data Ecosystem50