Supplementary Material for: Treatment of Chronic-Relapsing Pitted Keratolysis with Glycopyrronium Bromide Cream: case report

Introduction: Pitted keratolysis (PK) is a superficial bacterial infection located almost exclusively on the soles. The most important predisposing factor is hyperhidrosis. PK is characterized by small, isolated or confluent, crateriform, noninflammatory pits. Maceration and malodor are the two most important signs and symptoms. The therapy of PK is very often unsatisfactory. Case Presentation: Two patients with chronic-relapsing PK were successfully treated with a cream containing 1% glycopyrronium bromide, a new topical anticholinergic with anti-hyperhidrosis action. Conclusions: Although our experience is currently based on only two patients, glycopyrronium bromide cream can be taken into consideration for prevention of chronic-relapsing PK.