AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

ChEBI2016-03-09 更新2026-07-12 收录

细胞谱系分化

AMPK信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-77705 数据链接链接失效反馈

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AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

创建时间：

2016-03-09

小分子QF84139通过激活AMPK信号通路改善心肌肥厚

心肌肥厚

AMPK信号通路

1，离体新生大鼠心肌细胞体系，苯肾上腺素诱导肥大模型，通过药物或基因操作处理，研究小分子化合物抗心肌肥厚作用与机制；2，野生型小鼠，主动脉弓狭窄手术构建压力超负荷心肌肥厚模型，通过药物处理，研究小分子化合物抗心肌肥厚作用；3，AMPKα2敲除小鼠，主动脉弓缩窄手术构建压力超负荷心肌肥厚模型，用于证明小分子作用机制

干细胞与再生医学数据中心2023-05-25 更新120

Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures

人类胚胎多能性状态转变

细胞谱系分化

We describe the global cell fate roadmap during primed-to-naive transition process by bulk mRNA-seq and ATAC-seq analysis among transition intermediates across different time points. We report that ac

NIAID Data Ecosystem70

Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis

发育生物学

细胞谱系分化

Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary crest myofibroblasts (SCMF) exist

NIAID Data Ecosystem50

Resveratrol ameliorates lipid accumulation and inflammation in human SZ95 sebocytes via the AMPK signaling pathways in vitro

痤疮分子机制

AMPK信号通路

Background: Acne Vulgaris is one of the commonest dermatological challenges lacking effective and well-tolerated treatment. An earlier study indicated that resveratrol (RVT) exhibits therapeutic effec

NIAID Data Ecosystem110

Coactivator condensation drives cell lineage specification

细胞谱系分化

转录凝聚体

During development, cells make switch-like decisions to activate new gene programs specifying cell lineage. The mechanisms underlying these decisive choices remain unclear. Here we show that the cardi

NIAID Data Ecosystem60

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

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