Supporting Information.

This file contains: Code A, MATLAB Script for Model Runs. Code B, SBML Code for the Model. Equation A, Calculation of Percent Recruitment from the model results. Equation B, Calculation of Time-Averaged Numbers of ligand-bound AHR. Equation C, Calculation of Time-Averaged Numbers of cofactor bound to AHR-ARNT. Equation D, Equations used for Baseline Projection to determine Transitional Dose Values from Simon et al., (2014). Fig A, Dose-response to the number of ligand-bound AHR molecules as a function of TCDD concentration and fitted Hill functions. Fig B, Histograms of CYP1A1 mRNA copy number induced by TCDD. Table A, Compartments and Species. Table B, Reactions and Rate Constants. Table C, Comparison of classical rate constants, molecular rate constants and propensities. Table D, Hill Model fits of the Percentage of Cells with one or more CYP XRE bound. Table E, Goodness of fit of Poisson distribution for modeled CYP1A1 mRNA copy number.
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