Gene expression differences between Y123F and WT by Illumina Microarrays.
收藏Figshare2015-12-03 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_The_Influence_of_LepR_Tyrosine_Site_Mutations_on_Mouse_Ovary_Development_and_Related_Gene_Expression_Changes_/1592752
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S1 Table gives gene lists with significant changes of mRNA levels in ovaries of the mouse strain (denoted Y123F) with artificially mutated leptin receptors, with phenylalanine (F) substitution for all 3 tyrosine (Y) residues within exon 18 of LepRb of Tyr985, Tyr1077 and Tyr1138, with wild types of the same litter as the control. Y123F mice also manifested obesity, hyperphagia, hyperleptinemia, hyperinsulinemia and impairment in glucose tolerance. Young mice subjected to cDNA microarray analysis, LepR/WT indicated the Y123F signal value/control signal value. Ovarian tissues of 12 weeks old Y123F and Control mice was taken from 6 ovaries of 6 mice respectively, and then mixed into RNA pools for the DNA microarray analysis by United Gene Technology Co Ltd (Shanghai). Mouse WG-6 v2.0 chip (microarray chips, Illumina) was used as the mouse whole genome expression profiling bead chip. The original data were uploaded into GEO library (GSE73590). (DOCX)
创建时间：
2015-12-03
