Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antogonism of NF-κB pathway

NIAID Data Ecosystem2026-05-01 收录

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160573

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We report that BET inhibitor (I-BET762) protect against cytokine induced pancreatic beta-cell apoptosis and did RNA-Seq to determine global transcriptome changes with the drug. Rat insulinoma cell line (INS1) were treated with vehicle control (VC), I-BET762 (IB), ctyokine with vehicle control (CCVC) and cytokines with I-BET762 (CCIB) for 72h with cytokines added in last 24h. contributor: Novogene

创建时间：

2023-10-01