Replication Data for: Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

This is a replication dataset for the manuscript titled: \"Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.\" This dataset contains complete blood count data (platelet counts and total white blood cell counts) for severely ill patients enrolled in either studies of severe malaria or general severe febrile illness in Africa and Asia. For reproducibility of analyses we also provide parasite densities; hospital outcome; sickle trait status for the Kenyan children; plasma PfHRP2 for FEAST and Bangladesh adults; age. Variable Description: study: Vietnam (2 randomized trials in severe malaria: Hien et al; Phu et al); Bangladesh/Thailand (observational studies in severe malaria); FEAST (Maitland et); Kenya (KEMRI severe malaria cohort) platelets: number of platelets x1000 per uL of blood wbc: number of white blood cells x1000 per uL of blood pfhrp2: PfHRP2 concentration in plasma (ng/mL) age: years HbAS: sickle trait genotype (0: not sickle trait; 1: sickle trait) outcome: in hospital survival (0: survived; 1: died) parasitaemia: parasite density per uL of blood. The package presented contains data and replication code. The code is also available on github repo: code is on this github repo: https://github.com/jwatowatson/Kenyan_phenotypic_accuracy本数据集为题为《通过优化表型精度提升重症疟疾（severe malaria）遗传关联研究统计效力》的手稿的复刻数据集。本数据集涵盖在非洲与亚洲开展的重症疟疾或各类重症发热性疾病研究中入组的重症患者的全血细胞计数（complete blood count）数据，具体包括血小板计数与白细胞总数。为保障分析可复现，我们同时提供了寄生虫载量（parasite densities）、医院转归（hospital outcome）、肯尼亚儿童的镰状红细胞性状（sickle trait）状态、FEAST研究与孟加拉国成人的血浆PfHRP2水平以及年龄信息。 变量说明： study（研究分组）：越南（两项重症疟疾随机对照试验：Hien等人；Phu等人）；孟加拉国/泰国（重症疟疾观察性研究）；FEAST（Maitland等人）；肯尼亚（KEMRI重症疟疾队列） platelets（血小板计数）：每微升血液中的血小板数×1000 wbc（白细胞计数）：每微升血液中的白细胞数×1000 pfhrp2（血浆PfHRP2浓度）：血浆中PfHRP2浓度，单位为ng/mL age（年龄）：以岁为单位的年龄 HbAS（镰状红细胞性状基因型）：镰状红细胞性状状态（0：非镰状性状；1：镰状性状） outcome（院内转归）：院内生存状态（0：存活；1：死亡） parasitaemia（寄生虫载量）：每微升血液中的寄生虫密度 本数据包包含数据集与复刻代码。代码亦可从以下GitHub仓库获取：https://github.com/jwatowatson/Kenyan_phenotypic_accuracy