Supplementary Material for: A Complex Case of Anti-e Mimicking Autoantibody Development Leading to Warm Autoimmune Hemolytic Anemia: Case Report

Introduction: Newly diagnosed autoimmune hemolytic anemia (AIHA) develops in 1-3 individuals per 100,000 people per year. Warm autoimmune hemolytic anemia (WAIHA) is the most common type of AIHA, accounting for approximately 70-80% of cases. This report outlines complex presentation of DTA-negative, anti-e-mimicking autoantibody mediated WAIHA following a transient viral infection in an adult male patient with no prior transfusions.

Case Presentation: A 55-year-old male patient presented with several weeks of flu-like symptoms followed by jaundice, dyspnea, and fatigue with lab work up notable initially for an anti-C antibody mediated WAIHA but later determined to be an anti-e mimicking pan-agglutinating autoantibody.

Conclusion: This report highlights a complex case of a patient with an autoantibody mimicking anti-e associated WAIHA and the challenge of identifying suitable transfusion options.